PUMA BH3

• Target:

  Bcl-2 Family

• Related Pathways:

  Apoptosis

• Bioactivity:

  PUMA BH3 is a p53 upregulated modulator of apoptosis (PUMA) BH3 domain peptide that acts as a direct activator of Bak with a Kd of 26 nM. PUMA proteins bind Bcl-2, localize to the mitochondria, and induce cytochrome C release and apoptosis in response to p53, potentially mediating p53-induced apoptosis.

• Molecular Formula:

  C128H202N42O43S

• Molecular Weight:

  3049.3

• Shipping Conditions:

  Cool pack

• Storage Temperature:

  -20°C