α-Conotoxin BuIA

• CAS Number :

  846539-62-6

• Target :

  AChR

• Related Pathways :

  Neuroscience

• Bioactivity :

  ?-Conotoxin BuIA is a paralytic peptide neurotoxin that acts as a competitive antagonist of nicotinic acetylcholine receptors (nAChR), with inhibitory concentration 50 (IC50) values of 0.258 nM for ?6/?3?2, 1.54 nM for ?6/?3?4, and 5.72 nM for ?3?2. It serves to differentiate between nAChRs containing the ?2- and ?4-subunits and selectively inhibits ?x?2 nAChRs, exhibiting a potency hierarchy of ?6>?3>?2>?4 [1].

• Smiles :

  O=C1[C@]2(N(C(=O)[C@]([C@@H](C)O)(NC(=O)[C@H](CO)NC(=O)[C@]3(NC(=O)[C@@H](NC(CN)=O)CSSC[C@](NC(=O)[C@]4(N1CCC4)[H])(C(=O)N[C@@H](C)C(=O)N[C@@H]([C@H](C)C)C(=O)N[C@@H](CC(C)C)C(=O)N[C@@H](CC5=CC=C(O)C=C5)C(=O)N[C@H](C(N)=O)CSSC3)[H])[H])[H])CCC2)[H]

• Molecular Formula :

  C54H82N14O16S4

• Molecular Weight :

  1311.57

• Shipping Conditions :

  Cool pack

• Storage Temperature :

  -20°C