α-Conotoxin BuIA

CAT: 0931-T80166-01Size: 5 mgDry Ice: NoHazardous: No

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CAT#:0931-T80166-01Size:5 mg

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24/48H Stock Items & 2 to 6 Weeks non Stock Items.

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CAS Number

846539-62-6

Target

AChR

Related Pathways

Neuroscience

Bioactivity

α-Conotoxin BuIA is a paralytic peptide neurotoxin that acts as a competitive antagonist of nicotinic acetylcholine receptors (nAChR), with inhibitory concentration 50 (IC50) values of 0.258 nM for α6/α3β2, 1.54 nM for α6/α3β4, and 5.72 nM for α3β2. It serves to differentiate between nAChRs containing the β2- and β4-subunits and selectively inhibits αxβ2 nAChRs, exhibiting a potency hierarchy of α6>α3>α2>α4 [1].

Smiles

O=C1[C@]2(N(C(=O)[C@]([C@@H](C)O)(NC(=O)[C@H](CO)NC(=O)[C@]3(NC(=O)[C@@H](NC(CN)=O)CSSC[C@](NC(=O)[C@]4(N1CCC4)[H])(C(=O)N[C@@H](C)C(=O)N[C@@H]([C@H](C)C)C(=O)N[C@@H](CC(C)C)C(=O)N[C@@H](CC5=CC=C(O)C=C5)C(=O)N[C@H](C(N)=O)CSSC3)[H])[H])[H])CCC2)[H]

Molecular Formula

C54H82N14O16S4

Molecular Weight

1311.57

Shipping Conditions

Ice Packs

Storage Temperature

-20°C

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CON024	α-Conotoxin BuIA
MBS5821825	alpha-Conotoxin BuIA
MBS1255605-01	Recombinant Conus bullatus Alpha-conotoxin BuIA
063-35	BuIA
B5380-.5	α-Conotoxin EI
4030525.1000	Μ-Conotoxin GIIIA
4016344.1000	Μ-Conotoxin GIIIB
H-9015.1000	µ-Conotoxin GIIIB
H-7765.1000	a-Conotoxin MI
4013838.05	α-Conotoxin MI

α-Conotoxin BuIA

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