α-Conotoxin BuIA

• Target:

  AChR

• Related Pathways:

  Neuroscience

• Bioactivity:

  ?-Conotoxin BuIA is a paralytic peptide neurotoxin that acts as a competitive antagonist of nicotinic acetylcholine receptors (nAChR), with inhibitory concentration 50 (IC50) values of 0.258 nM for ?6/?3?2, 1.54 nM for ?6/?3?4, and 5.72 nM for ?3?2. It serves to differentiate between nAChRs containing the ?2- and ?4-subunits and selectively inhibits ?x?2 nAChRs, exhibiting a potency hierarchy of ?6>?3>?2>?4 [1].

• Smiles:

  O=C1[C@]2 (N (C (=O) [C@] ([C@@H] (C) O) (NC (=O) [C@H] (CO) NC (=O) [C@]3 (NC (=O) [C@@H] (NC (CN) =O) CSSC[C@] (NC (=O) [C@]4 (N1CCC4) [H]) (C (=O) N[C@@H] (C) C (=O) N[C@@H] ([C@H] (C) C) C (=O) N[C@@H] (CC (C) C) C (=O) N[C@@H] (CC5=CC=C (O) C=C5) C (=O) N[C@H] (C (N) =O) CSSC3) [H]) [H]) [H]) CCC2) [H]

• Molecular Formula:

  C54H82N14O16S4

• Molecular Weight:

  1311.57

• Shipping Conditions:

  Cool pack

• Storage Temperature:

  -20°C

• CAS Number:

  846539-62-6