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DOTA-LM3

CAT: 0931-T80155-01Size: 5 mgDry Ice: NoHazardous: No
CAT#:0931-T80155-01Size:5 mg
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24/48H Stock Items & 2 to 6 Weeks non Stock Items.
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CAS Number
1192362-32-5
Target
Somatostatin
Related Pathways
GPCR/G Protein
Bioactivity
DOTA-LM3 is a somatostatin receptor (SSTR) antagonist, with LM3 denoting the peptide sequence p-Cl-Phe-cyclo (D-Cys-Tyr-D-4-amino-Phe (carbamoyl) -Lys-Thr-Cys) D-Tyr-NH2. It is utilized in the isotopic labeling of tumors for in vivo tracing, notably with 177Lu-DOTA-LM3 and 68Ga-DOTA-LM3. The derivative 68Ga-DOTA-LM3 exhibits promising biodistribution, high tumor uptake, efficient tumor retention, and minimal safety concerns, while 177Lu-DOTA-LM3 is applied in research on DOTATOC-negative liver metastases including pancreatic NET and extensive tumor thrombosis [1] [2].
Smiles
C([C@H]1NC(=O)[C@H](CC2=CC=C(O)C=C2)NC(=O)[C@H](NC([C@H](CC3=CC=C(Cl)C=C3)NC(CN4CCN(CC(O)=O)CCN(CC(O)=O)CCN(CC(O)=O)CC4)=O)=O)CSSC[C@@H](C(N[C@H](CC5=CC=C(O)C=C5)C(N)=O)=O)NC(=O)[C@]([C@@H](C)O)(NC(=O)[C@H](CCCCN)NC1=O)[H])C6=CC=C(NC(N)=O)C=C6
Molecular Formula
C69H93ClN16O19S2
Molecular Weight
1550.16
Shipping Conditions
Cool pack
Storage Temperature
-20°C

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