DOTA-LM3

• Target:

  Somatostatin

• Related Pathways:

  GPCR/G Protein

• Bioactivity:

  DOTA-LM3 is a somatostatin receptor (SSTR) antagonist, with LM3 denoting the peptide sequence p-Cl-Phe-cyclo (D-Cys-Tyr-D-4-amino-Phe (carbamoyl) -Lys-Thr-Cys) D-Tyr-NH2. It is utilized in the isotopic labeling of tumors for in vivo tracing, notably with 177Lu-DOTA-LM3 and 68Ga-DOTA-LM3. The derivative 68Ga-DOTA-LM3 exhibits promising biodistribution, high tumor uptake, efficient tumor retention, and minimal safety concerns, while 177Lu-DOTA-LM3 is applied in research on DOTATOC-negative liver metastases including pancreatic NET and extensive tumor thrombosis [1] [2].

• Smiles:

  C ([C@H]1NC (=O) [C@H] (CC2=CC=C (O) C=C2) NC (=O) [C@H] (NC ([C@H] (CC3=CC=C (Cl) C=C3) NC (CN4CCN (CC (O) =O) CCN (CC (O) =O) CCN (CC (O) =O) CC4) =O) =O) CSSC[C@@H] (C (N[C@H] (CC5=CC=C (O) C=C5) C (N) =O) =O) NC (=O) [C@] ([C@@H] (C) O) (NC (=O) [C@H] (CCCCN) NC1=O) [H]) C6=CC=C (NC (N) =O) C=C6

• Molecular Formula:

  C69H93ClN16O19S2

• Molecular Weight:

  1550.16

• Shipping Conditions:

  Cool pack

• Storage Temperature:

  -20°C

• CAS Number:

  1192362-32-5