JET-209

• Target :

  Histone Acetyltransferase|||PROTACs

• Related Pathways :

  Chromatin/Epigenetic|||PROTAC

• Bioactivity :

  JET-209 is a potent proteolysis-targeting chimera (PROTAC) that effectively degrades CBP/p300, exhibiting half-maximal degradation concentration (DC50) values of 0.05 nM for CBP and 0.2 nM for p300. The compound comprises lenalidomide (the cereblon ligand), a connecting linker, and GNE-207 (the bromodomain inhibitor) . JET-209 is utilized in cancer research [1].

• Molecular Formula :

  C46H47N9O6

• Molecular Weight :

  821.92

• Shipping Conditions :

  Cool pack

• Storage Temperature :

  -20°C