JET-209

• Target:

  Histone Acetyltransferase|||PROTACs

• Related Pathways:

  Chromatin/Epigenetic|||PROTAC

• Bioactivity:

  JET-209 is a potent proteolysis-targeting chimera (PROTAC) that effectively degrades CBP/p300, exhibiting half-maximal degradation concentration (DC50) values of 0.05 nM for CBP and 0.2 nM for p300. The compound comprises lenalidomide (the cereblon ligand), a connecting linker, and GNE-207 (the bromodomain inhibitor) . JET-209 is utilized in cancer research [1].

• Molecular Formula:

  C46H47N9O6

• Molecular Weight:

  821.92

• Shipping Conditions:

  Cool pack

• Storage Temperature:

  -20°C