FEN1-IN-7

• Target :

  FLAP

• Related Pathways :

  Immunology/Inflammation

• Bioactivity :

  FEN1-IN-7 (compound 16), a selective Flap endonuclease-1 (FEN1) inhibitor with an IC50 of 18 nM, plays a role in DNA damage repair in mammalian cells. Additionally, it targets the related endonuclease, xeroderma pigmentosum G (XPG), with an IC50 of 3.04 ?M. FEN1-IN-7 enhances the sensitivity of cancer cells to potent DNA alkylating or methylating agents [1].

• Smiles :

  C(N1C2=C(C(=O)N(O)C1=O)C(C)=CS2)C=3C=C4C(=C(OC)C3)OCO4

• Molecular Formula :

  C16H14N2O6S

• Molecular Weight :

  362.36

• Shipping Conditions :

  Cool pack

• Storage Temperature :

  -20°C

• CAS Number :

  824983-90-6