JBI-589

• CAS Number :

  2308504-22-3

• Target :

  Others|||PAD

• Related Pathways :

  Chromatin/Epigenetic|||Others

• Bioactivity :

  JBI-589 is an isoform-selective, non-covalent inhibitor of PAD4 that diminishes CXCR2 expression and impedes neutrophil chemotaxis. Additionally, it attenuates primary tumor growth and metastases, augmenting the efficacy of checkpoint inhibitors [1].

• Smiles :

  C(N1C(=CC=2C1=CC=CC2)C3=C(C)N4C(=N3)C=C(C(=O)N5C[C@H](N)CCC5)C=C4)C6=CC=C(F)C=C6

• Molecular Formula :

  C29H28FN5O

• Molecular Weight :

  481.56

• Shipping Conditions :

  Cool pack

• Storage Temperature :

  -20°C