JBI-589

• Target:

  Others|||PAD

• Related Pathways:

  Chromatin/Epigenetic|||Others

• Bioactivity:

  JBI-589 is an isoform-selective, non-covalent inhibitor of PAD4 that diminishes CXCR2 expression and impedes neutrophil chemotaxis. Additionally, it attenuates primary tumor growth and metastases, augmenting the efficacy of checkpoint inhibitors [1].

• Smiles:

  C(N1C(=CC=2C1=CC=CC2)C3=C(C)N4C(=N3)C=C(C(=O)N5C[C@H](N)CCC5)C=C4)C6=CC=C(F)C=C6

• Molecular Formula:

  C29H28FN5O

• Molecular Weight:

  481.56

• Shipping Conditions:

  Cool pack

• Storage Temperature:

  -20°C

• CAS Number:

  2308504-22-3