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JT002

CAT: 0931-T78822-01Size: 5 mgDry Ice: NoHazardous: No
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CAT#:0931-T78822-01Size:5 mg
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24/48H Stock Items & 2 to 6 Weeks non Stock Items.
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CAS Number
2238820-43-2
Target
NOD-like Receptor (NLR)
Related Pathways
Immunology/Inflammation
Bioactivity
JT002 is an orally active NLRP3 inflammasome inhibitor that decreases the production of NLRP3-dependent proinflammatory cytokines (such as IL-1β, IL-1α, IL-18) and pyroptosis, as well as inhibits the formation of the NLRP3 inflammasome complex. Additionally, JT002 mitigates airway hyperresponsiveness and airway neutrophilia in mice [1].
Smiles
N(C(NS(=O)(=O)C1=C2N(N=C1)C[C@H](OC)CO2)=O)C3=C4C(=CC5=C3CCC5)CCC4
Molecular Formula
C20H24N4O5S
Molecular Weight
432.49
Shipping Conditions
Ice Packs
Storage Temperature
-20°C

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