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JT002

CAT: 0804-HY-149478-01Size: 1 mgDry Ice: NoHazardous: No
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CAT#:0804-HY-149478-01Size:1 mg
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24/48H Stock Items & 2 to 6 Weeks non Stock Items.
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Description
JT002 is an orally active and selective NLRP3 inflammasome assembly inhibitor. JT002 reduces NLRP3-dependent proinflammatory cytokine (such as IL-1β, IL-1α, IL-18) production and pyroptosis. JT002 blocks NLRP3 inflammasome complex formation. JT002 reduces airway hyperresponsiveness and airway neutrophilia in mice. JT002 can be used for the study of a variety of inflammatory diseases, such as Muckle-Wells syndrome (MWS) [1].
CAS Number
2238820-43-2
UNSPSC
12352005
Target
NOD-like Receptor (NLR) ; Pyroptosis
Type
Reference compound
Related Pathways
Apoptosis; Immunology/Inflammation
Applications
COVID-19-immunoregulation
Field of Research
Inflammation/Immunology
Assay Protocol
https://www.medchemexpress.com/jt002.html
Purity
99.54
Solubility
DMSO : 100 mg/mL (ultrasonic)
Smiles
O=C(NS(=O)(C1=C(OC[C@@H](OC)C2)N2N=C1)=O)NC3=C(CCC4)C4=CC5=C3CCC5
Molecular Formula
C20H24N4O5S
Molecular Weight
432.49
References & Citations
[1]Ambrus-Aikelin G, et al. JT002, a small molecule inhibitor of the NLRP3 inflammasome for the treatment of autoinflammatory disorders. Sci Rep. 2023 Aug 19;13 (1) :13524.
Shipping Conditions
Room Temperature
Storage Conditions
-20°C, 3 years; 4°C, 2 years (Powder)
Scientific Category
Reference compound1
Clinical Information
Phase 2

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