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MDMX/MDM2-IN-2

CAT: 0931-T78699-01Size: 5 mgDry Ice: NoHazardous: No
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CAT#:0931-T78699-01Size:5 mg
Selected
24/48H Stock Items & 2 to 6 Weeks non Stock Items.
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Target
Apoptosis, Others, MDM-2/p53
Related Pathways
Others, Apoptosis
Bioactivity
MDMX/MDM2-IN-2 is a potent dual inhibitor of p53-MDM2/MDMX, with dissociation constants (Kis) of 0.23 μM for MDM2 and 2.45 μM for MDMX. It disrupts the interaction between p53 and MDM2 proteins, reinstating p53 functionality to induce cell cycle arrest and apoptosis. Additionally, this compound impedes cell migration and invasion, exhibiting notable antitumor activity [1].
Molecular Formula
C28H25Cl3FN3O3
Molecular Weight
576.87
Shipping Conditions
Ice Packs
Storage Temperature
-20°C

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