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2′-Thioadenosine

CAT: 0931-T78634-01Size: 25 mgDry Ice: NoHazardous: No
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CAT#:0931-T78634-01Size:25 mg
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24/48H Stock Items & 2 to 6 Weeks non Stock Items.
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CAS Number
136904-69-3
Target
EGFR
Related Pathways
Tyrosine Kinase/Adaptors, JAK/STAT signaling, Angiogenesis
Bioactivity
2'-Thioadenosine (PD157432) serves as a selective and irreversible inhibitor of ErbB-1 and ErbB-2 tyrosine kinases, demonstrating an IC50 value of 45 μM against ErbB-2. It achieves covalent inactivation of ErbB-1 through modification of a cysteine residue within the enzyme's active site [1].
Smiles
S[C@H]1[C@H](N2C=3C(N=C2)=C(N)N=CN3)O[C@H](CO)[C@H]1O
Molecular Formula
C10H13N5O3S
Molecular Weight
283.31
Shipping Conditions
Ice Packs
Storage Temperature
-20°C

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