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Clervonafusp alfa

CAT: 0931-T77131-01Size: 5 mgDry Ice: NoHazardous: No
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CAT#:0931-T77131-01Size:5 mg
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24/48H Stock Items & 2 to 6 Weeks non Stock Items.
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CAS Number
2145123-44-8
Target
Glycosidase, Glucosidase
Related Pathways
Metabolism
Bioactivity
Clervonafusp alfa (VAL-1221) is a fusion protein targeting both cytosolic and lysosomal glycogen, addressing the mechanisms of Pompe disease. It combines the Fab segment of a cell-penetrating antibody with recombinant human acid alpha-glucosidase (rhGAA) . The Fab portion utilizes the nucleoside transporter ENT-2 for cytosolic entry, while rhGAA accesses lysosomes via mannose-6-phosphate receptors (M6PRs) . This dual-targeting approach suggests Clervonafusp alfa as a potential therapeutic research candidate for late-onset Pompe disease [1].
Shipping Conditions
Ice Packs
Storage Temperature
-20°C

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