CKLF1-C27

• Target:

  ERK|||CCR

• Related Pathways:

  Microbiology/Virology|||Immunology/Inflammation|||GPCR/G Protein|||MAPK

• Bioactivity:

  CKLF1-C27, a C-terminal peptide of CKLF1, effectively binds to and activates the CCR4 receptor, triggering the ERK1/2 pathway. Competing with CKLF1 for the CCR4 receptor, it neutralizes CKLF1's cellular effects. Additionally, CKLF1-C27 significantly promotes the proliferation of HUVECs and holds promise for psoriasis research [1].

• Smiles:

  C ([C@@H] (NC ([C@@H] (NC ([C@@H] (NC ([C@@H] (NC (=O) [C@H]1N (C (CNC ([C@@H] (NC (=O) [C@H]2N (C ([C@@H] (NC ([C@H] (CC3=CC=CC=C3) NC ([C@@H] (NC ([C@@H] (NC ([C@@H] (NC ([C@@H] (NC ([C@H] (CC4=CC=C (O) C=C4) NC ([C@@H] (NC ([C@@H] (NC ([C@H] (C) N) =O) CC (C) C) =O) [C@H] (CC) C) =O) =O) CCCNC (=N) N) =O) CCCCN) =O) CC (C) C) =O) CC (C) C) =O) =O) CC (N) =O) =O) CCC2) CO) =O) =O) CCC1) CC5=CC=C (O) C=C5) =O) CCC (N) =O) =O) CCCCN) =O) CCCCN) (=O) N6[C@H] (C (N[C@H] (C (N[C@@H] (CC7=CN=CN7) C (N[C@H] (C (N[C@H] (C (N[C@H] (C (N[C@H] (C (N[C@H] (C (N[C@@H] (CC (C) C) C (O) =O) =O) C (C) C) =O) CCC (O) =O) =O) CCCCN) =O) CCCCN) =O) CCC (O) =O) =O) =O) C (C) C) =O) CCC6

• Molecular Formula:

  C151H243N39O37

• Molecular Weight:

  3196.78

• Shipping Conditions:

  Cool pack

• Storage Temperature:

  -20°C

• CAS Number:

  891861-48-6