CKLF1-C27

• Target :

  ERK|||CCR

• Related Pathways :

  Microbiology/Virology|||Immunology/Inflammation|||GPCR/G Protein|||MAPK

• Bioactivity :

  CKLF1-C27, a C-terminal peptide of CKLF1, effectively binds to and activates the CCR4 receptor, triggering the ERK1/2 pathway. Competing with CKLF1 for the CCR4 receptor, it neutralizes CKLF1's cellular effects. Additionally, CKLF1-C27 significantly promotes the proliferation of HUVECs and holds promise for psoriasis research [1].

• Smiles :

  C([C@@H](NC([C@@H](NC([C@@H](NC([C@@H](NC(=O)[C@H]1N(C(CNC([C@@H](NC(=O)[C@H]2N(C([C@@H](NC([C@H](CC3=CC=CC=C3)NC([C@@H](NC([C@@H](NC([C@@H](NC([C@@H](NC([C@H](CC4=CC=C(O)C=C4)NC([C@@H](NC([C@@H](NC([C@H](C)N)=O)CC(C)C)=O)[C@H](CC)C)=O)=O)CCCNC(=N)N)=O)CCCCN)=O)CC(C)C)=O)CC(C)C)=O)=O)CC(N)=O)=O)CCC2)CO)=O)=O)CCC1)CC5=CC=C(O)C=C5)=O)CCC(N)=O)=O)CCCCN)=O)CCCCN)(=O)N6[C@H](C(N[C@H](C(N[C@@H](CC7=CN=CN7)C(N[C@H](C(N[C@H](C(N[C@H](C(N[C@H](C(N[C@H](C(N[C@@H](CC(C)C)C(O)=O)=O)C(C)C)=O)CCC(O)=O)=O)CCCCN)=O)CCCCN)=O)CCC(O)=O)=O)=O)C(C)C)=O)CCC6

• Molecular Formula :

  C151H243N39O37

• Molecular Weight :

  3196.78

• Shipping Conditions :

  Cool pack

• Storage Temperature :

  -20°C

• CAS Number :

  891861-48-6