Leptin (116-130)

• Target:

  IGluR

• Related Pathways:

  Neuroscience|||Membrane transporter/Ion channel

• Bioactivity:

  Leptin (116-130), a bioactive fragment of leptin, enhances synaptic plasticity in the hippocampus by promoting AMPA receptor trafficking to synapses. It preserves hippocampal synapse integrity and prevents neuronal cell death in amyloid toxicity models, showing promise for Alzheimer's disease (AD) research [1].

• Smiles:

  C([C@@H](NC([C@@H](NC([C@@H](NC(CNC([C@@H](NC([C@@H](NC([C@@H](NC(=O)[C@H]1N(C([C@@H](NC([C@@H](NC([C@@H](NC([C@H](CO)N)=O)CS)=O)CO)=O)CC(C)C)=O)CCC1)CCC(N)=O)=O)[C@@H](C)O)=O)CO)=O)=O)CC(C)C)=O)CCC(N)=O)=O)CCCCN)(=O)N2[C@H](C(N[C@H](C(N[C@H](C(O)=O)CO)=O)CCC(O)=O)=O)CCC2

• Molecular Formula:

  C64H108N18O25S

• Molecular Weight:

  1561.72

• Shipping Conditions:

  Cool pack

• Storage Temperature:

  -20°C

• CAS Number:

  189224-35-9