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(±) -Evodiamine

CAT: 0931-T75424-01Size: 1 mL - 10 mM (in DMSO)Dry Ice: NoHazardous: No
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CAT#:0931-T75424-01Size:1 mL - 10 mM (in DMSO)
Selected
24/48H Stock Items & 2 to 6 Weeks non Stock Items.
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CAS Number
518-18-3
Target
STAT, IL Receptor, Apoptosis, IGF-1R, Topoisomerase, HIF
Related Pathways
Chromatin/Epigenetic, Tyrosine Kinase/Adaptors, JAK/STAT signaling, Angiogenesis, DNA Damage/DNA Repair, Immunology/Inflammation, Stem Cells, Apoptosis
Purity
0.99904
Bioactivity
(±) -Evodiamine is an alkaloid isolated from Evodiae fructus and a topoisomerase I inhibitor. It also inhibits adipocyte differentiation and diabetes by downregulating IGF-1/HIF-1α and IL-6/STAT pathways. As an inhibitor of NF-κB activation, it suppresses invasion, promotes apoptosis, and inhibits TNF-induced Akt activation.
Smiles
CN1C2C3=C(C=4C(N3)=CC=CC4)CCN2C(=O)C=5C1=CC=CC5
Molecular Formula
C19H17N3O
Molecular Weight
303.36
Shipping Conditions
Ice Packs
Storage Temperature
-20°C

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