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BAY-747

CAT: 0931-T75137-01Size: 100 mgDry Ice: NoHazardous: No
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CAT#:0931-T75137-01Size:100 mg
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24/48H Stock Items & 2 to 6 Weeks non Stock Items.
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CAS Number
1609342-18-8
Target
Others, Guanylate cyclase
Related Pathways
Others, GPCR/G Protein
Bioactivity
BAY-747 (BAY 1165747) is an orally administered, brain-penetrant compound that stimulates soluble guanylate cyclase (sGC) . It effectively counteracts memory impairments induced by L-NAME, improves cognitive performance in rats during the object location task (OLT), reduces blood pressure in conscious normotensive and spontaneously hypertensive rats (SHR), and enhances skeletal muscle function in the mdx/mTRG2 mouse model of Duchenne muscular dystrophy (DMD) [1] [2] [3].
Smiles
O(CC1=C(F)C=CC=C1F)C=2C=3N(C(C(NC[C@@](CC)(C)N)=O)=C(C)N3)C=C(C)C2
Molecular Formula
C22H26F2N4O2
Molecular Weight
416.46
Shipping Conditions
Ice Packs
Storage Temperature
-20°C

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