BAY-747

• Target :

  Others|||Guanylate cyclase

• Related Pathways :

  Others|||GPCR/G Protein

• Bioactivity :

  BAY-747 (BAY 1165747) is an orally administered, brain-penetrant compound that stimulates soluble guanylate cyclase (sGC) . It effectively counteracts memory impairments induced by L-NAME, improves cognitive performance in rats during the object location task (OLT), reduces blood pressure in conscious normotensive and spontaneously hypertensive rats (SHR), and enhances skeletal muscle function in the mdx/mTRG2 mouse model of Duchenne muscular dystrophy (DMD) [1] [2] [3].

• Smiles :

  O(CC1=C(F)C=CC=C1F)C=2C=3N(C(C(NC[C@@](CC)(C)N)=O)=C(C)N3)C=C(C)C2

• Molecular Formula :

  C22H26F2N4O2

• Molecular Weight :

  416.46

• Shipping Conditions :

  Cool pack

• Storage Temperature :

  -20°C

• CAS Number :

  1609342-18-8