Products for Research Use Only
RegisterLogin

SZUH280

CAT: 0931-T75021-01Size: 5 mgDry Ice: NoHazardous: No
Product image 1
1 / 1
CAT#:0931-T75021-01Size:5 mg
Selected
24/48H Stock Items & 2 to 6 Weeks non Stock Items.
Quick Request Actions
CAS Number
2770263-77-7
Target
PROTACs, Apoptosis, Others, DNA/RNA Synthesis, HDAC
Related Pathways
Chromatin/Epigenetic, Apoptosis, Cell Cycle/Checkpoint, Others, DNA Damage/DNA Repair, PROTAC
Bioactivity
SZUH280 is a potent, selective PROTAC (proteolysis targeting chimera) HDAC8 (histone deacetylase 8) degrader, demonstrating a DC50 of 0.58 μM in A549 cells. It induces apoptosis in cancer cells and impedes DNA damage repair, thereby enhancing cellular radiosensitization [1].
Smiles
N(CC1=CN(CCOCCOC2=CC=C(CN3C=4C(C=C3)=CC=C(C(NO)=O)C4)C=C2)N=N1)C5=C6C(C(=O)N(C6=O)C7C(=O)NC(=O)CC7)=CC=C5
Molecular Formula
C36H34N8O8
Molecular Weight
706.7
Shipping Conditions
Ice Packs
Storage Temperature
-20°C

Alternative Products

CatalogName
HY-152147-01SZUH280

Popular Products