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SZUH280

CAT: 0013-GTR19220708-02Size: 50 mgDry Ice: NoHazardous: No
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CAT#:0013-GTR19220708-02Size:50 mg
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24/48H Stock Items & 2 to 6 Weeks non Stock Items.
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Description
SZUH280 is a potent and selective PROTAC HDAC8 degrader with a DC50 of 0.58 μM in A549 cells. It promotes cancer cell apoptosis, inhibits DNA damage repair, and acts as a radiosensitizer, making it a valuable tool for oncology research in both cellular and animal models.
CAS Number
2770263-77-7
Field of Research
Cell Biology, Epigenetics & Chromatin, Molecular Biology, Pharmacology & Drug Discovery
Smiles
N (CC1=CN (CCOCCOC2=CC=C (CN3C=4C (C=C3) =CC=C (C (NO) =O) C4) C=C2) N=N1) C5=C6C (C (=O) N (C6=O) C7C (=O) NC (=O) CC7) =CC=C5
Molecular Formula
C36H34N8O8
Molecular Weight
706.7
Storage Conditions
-20°C
Notes
For research use only.

Chemical Information

1-(4-(2-(2-(4-(((2-(2,6-Dioxopiperidin-3-yl)-1,3-dioxoisoindolin-4-yl)amino)methyl)-1H-1,2,3-triazol-1-yl)ethoxy)ethoxy)benzyl)-N-hydroxy-1H-indole-6-carboxamide
CAS Number2770263-77-7
PubChem CID166642477
IUPAC Name1-[[4-[2-[2-[4-[[[2-(2,6-dioxopiperidin-3-yl)-1,3-dioxoisoindol-4-yl]amino]methyl]triazol-1-yl]ethoxy]ethoxy]phenyl]methyl]-N-hydroxyindole-6-carboxamide
Molecular FormulaC36H34N8O8
Molecular Weight706.7
XLogP1.9
Topological Polar Surface Area199
Hydrogen Bond Donor Count4
Hydrogen Bond Acceptor Count11
Rotatable Bond Count14
Heavy Atom Count52
Formal Charge0
Complexity1310
SMILES
C1CC(=O)NC(=O)C1N2C(=O)C3=C(C2=O)C(=CC=C3)NCC4=CN(N=N4)CCOCCOC5=CC=C(C=C5)CN6C=CC7=C6C=C(C=C7)C(=O)NO
InChI
InChI=1S/C36H34N8O8/c45-31-11-10-29(34(47)38-31)44-35(48)27-2-1-3-28(32(27)36(44)49)37-19-25-21-43(41-39-25)14-15-51-16-17-52-26-8-4-22(5-9-26)20-42-13-12-23-6-7-24(18-30(23)42)33(46)40-50/h1-9,12-13,18,21,29,37,50H,10-11,14-17,19-20H2,(H,40,46)(H,38,45,47)
InChIKey
OCXICBCMNKOWFI-UHFFFAOYSA-N
Chemical Structure
2D Structure
2D structure of 1-(4-(2-(2-(4-(((2-(2,6-Dioxopiperidin-3-yl)-1,3-dioxoisoindolin-4-yl)amino)methyl)-1H-1,2,3-triazol-1-yl)ethoxy)ethoxy)benzyl)-N-hydroxy-1H-indole-6-carboxamide
CAS: 2770263-77-7
CID: 166642477
Formula: C36H34N8O8
MW: 706.7
Interactive 3D Structure
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View on PubChemRaw 3D data
Computed Properties
PropertyValue
Molecular Weight706.7
XLogP31.9
Hydrogen Bond Donor Count4
Hydrogen Bond Acceptor Count11
Rotatable Bond Count14
Exact Mass706.24996007
Monoisotopic Mass706.24996007
Topological Polar Surface Area199 Ų
Heavy Atom Count52
Formal Charge0
Complexity1310
Isotope Atom Count0
Defined Atom Stereocenter Count0
Undefined Atom Stereocenter Count1
Defined Bond Stereocenter Count0
Undefined Bond Stereocenter Count0
Covalently-Bonded Unit Count1
Compound Is CanonicalizedYes

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CatalogName
T75021-01SZUH280

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