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LL-K8-22

CAT: 0931-T74784-01Size: 5 mgDry Ice: NoHazardous: No
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CAT#:0931-T74784-01Size:5 mg
Selected
24/48H Stock Items & 2 to 6 Weeks non Stock Items.
Quick Request Actions
Target
CDK, Others, Early 2 Factor (E2F), PROTACs, STAT
Related Pathways
Cell Cycle/Checkpoint, JAK/STAT signaling, Others, Stem Cells, PROTAC
Bioactivity
LL-K8-22 is a potent, selective, and durable dual degrader of CDK8-cyclin C, demonstrating DC50 values of 2.52 and 2.64 μM, respectively. This compound effectively suppresses STAT1 Ser 727 phosphorylation and inhibits carcinogenic transcriptional programs driven by E2F and MYC. LL-K8-22 is specifically utilized in research for triple-negative breast cancer (TNBC) [1].
Molecular Formula
C37H43N5O
Molecular Weight
573.77
Shipping Conditions
Ice Packs
Storage Temperature
-20°C

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