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NecroIr2

CAT: 0931-T74681-01Size: 5 mgDry Ice: NoHazardous: No
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CAT#:0931-T74681-01Size:5 mg
Selected
24/48H Stock Items & 2 to 6 Weeks non Stock Items.
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Target
RIP kinase, CDK, Others, MLK
Related Pathways
Cell Cycle/Checkpoint, MAPK, Apoptosis, Others, NF-κB
Bioactivity
NecroIr2, an iridium (III) complex, functions as a necroptosis inducer in cisplatin-resistant lung cancer cells (A549R) . It preferentially accumulates in mitochondria, causing oxidative stress and a reduction in mitochondrial membrane potential (MMP) . Moreover, NecroIr2 initiates the activation of receptor-interacting serine/threonine kinase 3 (RIPK3) and mixed lineage kinase domain-like pseudokinase (MLKL), while also regulating CDK4 expression [1].
Molecular Formula
C46H30ClIrN6O2-
Molecular Weight
926.44
Shipping Conditions
Ice Packs
Storage Temperature
-20°C

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