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PP-C8

CAT: 0931-T74359-01Size: 5 mgDry Ice: NoHazardous: No
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CAT#:0931-T74359-01Size:5 mg
Selected
24/48H Stock Items & 2 to 6 Weeks non Stock Items.
Quick Request Actions
Target
PROTACs, CDK
Related Pathways
PROTAC, Cell Cycle/Checkpoint
Bioactivity
PP-C8, a potent and selective PROTAC CDK12-Cyclin K degrader, efficiently induces degradation of CDK12 and Cyclin K, with DC50 values of 416 nM and 412 nM, respectively. This compound exhibits significant synergistic antiproliferative effects when combined with a PARP inhibitor in triple-negative breast cancer (TNBC) [1].
Molecular Formula
C43H51FN12O7
Molecular Weight
866.94
Shipping Conditions
Ice Packs
Storage Temperature
-20°C

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