PP-C8

• Target:

  PROTACs|||CDK

• Related Pathways:

  PROTAC|||Cell Cycle/Checkpoint

• Bioactivity:

  PP-C8, a potent and selective PROTAC CDK12-Cyclin K degrader, efficiently induces degradation of CDK12 and Cyclin K, with DC50 values of 416 nM and 412 nM, respectively. This compound exhibits significant synergistic antiproliferative effects when combined with a PARP inhibitor in triple-negative breast cancer (TNBC) [1].

• Molecular Formula:

  C43H51FN12O7

• Molecular Weight:

  866.94

• Shipping Conditions:

  Cool pack

• Storage Temperature:

  -20°C