PP-C8
- Availability: 24/48H Stock Items & 2 to 6 Weeks non Stock Items.
- Dry Ice Shipment: No
PP-C8
Target :
PROTACs|||CDKRelated Pathways :
PROTAC|||Cell Cycle/CheckpointBioactivity :
PP-C8, a potent and selective PROTAC CDK12-Cyclin K degrader, efficiently induces degradation of CDK12 and Cyclin K, with DC50 values of 416 nM and 412 nM, respectively. This compound exhibits significant synergistic antiproliferative effects when combined with a PARP inhibitor in triple-negative breast cancer (TNBC) [1].Molecular Formula :
C43H51FN12O7Molecular Weight :
866.94Shipping Conditions :
Cool packStorage Temperature :
-20°C
