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O6BTG-C8-αGlu

CAT: 0931-T205643-01Size: 10 mgDry Ice: NoHazardous: No
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CAT#:0931-T205643-01Size:10 mg
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24/48H Stock Items & 2 to 6 Weeks non Stock Items.
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CAS Number
793035-88-8
Target
DNA Methyltransferase
Related Pathways
Chromatin/Epigenetic
Bioactivity
O6BTG-C8-αGlu is an O6-methylguanine-DNA methyltransferase (MGMT) inhibitor with an IC50 of 0.45 μM. At a concentration of 0.1 μM, it fully inhibits MGMT in HeLaS3 cells and demonstrates no cytotoxicity even at prolonged high doses (up to 20 μM) . This compound is suitable for research on MGMT-related cancers.
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O(CC1=CC(Br)=CS1)C2=C3C(N(CCCCCCCCO[C@H]4O[C@H](CO)[C@@H](O)[C@H](O)[C@H]4O)C=N3)=NC(N)=N2
Molecular Formula
C24H34BrN5O7S
Molecular Weight
616.525
Shipping Conditions
Ice Packs
Storage Temperature
-20°C

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