Prostaglandin J2

• Target:

  Endogenous Metabolite|||Others|||Prostaglandin Receptor

• Related Pathways:

  Metabolism|||GPCR/G Protein|||Immunology/Inflammation|||Others

• Bioactivity:

  Prostaglandin J2 (PGJ2), a derivative of Prostaglandin D2 (PGD2), serves as a potent agonist for PGD2 receptors (DP), exhibiting affinity constants (K i) of 0.9 nM and 6.6 nM for hDP and hCRTH2 receptors, respectively. It activates cyclic AMP production with an EC50 of 1.2 nM, induces oxidative stress, neuronal apoptosis, and promotes the accumulation of ubiquitinated (Ub) proteins. Notably, PGJ2's neurotoxic properties are implicated in the progression of neurodegenerative diseases such as Alzheimer's (AD) and Parkinson's (PD) [1] [2] [3] [4].

• Smiles:

  CCCCC[C@H] (O) \C=C\[C@@H]1[C@@H] (C\C=C/CCCC (O) =O) C=CC1=O

• Molecular Formula:

  C20H30O4

• Molecular Weight:

  334.45

• Shipping Conditions:

  Cool pack

• Storage Temperature:

  -20°C

• CAS Number:

  60203-57-8