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Prostaglandin J2

CAT: 0931-T73782-01Size: 500 µgDry Ice: NoHazardous: No
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CAT#:0931-T73782-01Size:500 µg
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24/48H Stock Items & 2 to 6 Weeks non Stock Items.
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CAS Number
60203-57-8
Target
Endogenous Metabolite, Others, Prostaglandin Receptor
Related Pathways
Metabolism, GPCR/G Protein, Immunology/Inflammation, Others
Bioactivity
Prostaglandin J2 (PGJ2), a derivative of Prostaglandin D2 (PGD2), serves as a potent agonist for PGD2 receptors (DP), exhibiting affinity constants (K i) of 0.9 nM and 6.6 nM for hDP and hCRTH2 receptors, respectively. It activates cyclic AMP production with an EC50 of 1.2 nM, induces oxidative stress, neuronal apoptosis, and promotes the accumulation of ubiquitinated (Ub) proteins. Notably, PGJ2's neurotoxic properties are implicated in the progression of neurodegenerative diseases such as Alzheimer's (AD) and Parkinson's (PD) [1] [2] [3] [4].
Smiles
CCCCC[C@H](O)\C=C\[C@@H]1[C@@H](C\C=C/CCCC(O)=O)C=CC1=O
Molecular Formula
C20H30O4
Molecular Weight
334.45
Shipping Conditions
Ice Packs
Storage Temperature
-20°C

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