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HI5

CAT: 0931-T73581-01Size: 25 mgDry Ice: NoHazardous: No
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CAT#:0931-T73581-01Size:25 mg
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24/48H Stock Items & 2 to 6 Weeks non Stock Items.
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CAS Number
2411548-90-6
Target
Others, Microtubule Associated, IDO, Apoptosis, Indoleamine 2,3-Dioxygenase (IDO)
Related Pathways
Metabolism, Apoptosis, Cytoskeletal Signaling, Others
Bioactivity
HI5, a potent inhibitor of tubulin and indoleamine 2,3-dioxygenase (IDO), exhibits an inhibitory concentration (IC50) of 70 nM in HeLa cells. It suppresses IDO expression, reduces kynurenine production, and enhances T cell activation and proliferation. Additionally, HI5 impedes tubulin polymerization and cell migration, induces G2/M phase arrest, and leads to apoptosis through the mitochondrial-dependent apoptosis pathway while generating reactive oxidative stress in HeLa cells, making it a valuable compound for anticancer research.
Smiles
C(C(C(OCCC1=CN(CC2=CC(C(OC3=C(OC)C=CC(/C=C\C4=CC(OC)=C(OC)C(OC)=C4)=C3)=O)=CC=C2)N=N1)=O)N)C=5C=6C(N(C)C5)=CC=CC6
Molecular Formula
C42H43N5O8
Molecular Weight
745.82
Shipping Conditions
Ice Packs
Storage Temperature
-20°C

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