SZM-1209

• Target:

  MLK|||Necroptosis|||RIP kinase

• Related Pathways:

  NF-?B|||Apoptosis|||MAPK

• Bioactivity:

  SZM-1209 is a potent and specific RIPK1 inhibitor with oral activity, displaying a dissociation constant (Kd) of 85 nM. It demonstrates substantial anti-necroptotic efficacy with an EC50 of 22.4 ± 8.1 nM and possesses therapeutic effects against systemic inflammatory response syndrome (SIRS) and acute lung injury (ALI) [1].

• Molecular Formula:

  C31H29F5N4O5S2

• Molecular Weight:

  696.71

• Shipping Conditions:

  Cool pack

• Storage Temperature:

  -20°C

• CAS Number:

  2919801-86-6