BTK-IN-17

• Target :

  Others|||BTK

• Related Pathways :

  Angiogenesis|||Others|||Tyrosine Kinase/Adaptors

• Bioactivity :

  BTK-IN-17 is a selective, orally active inhibitor of Bruton's Tyrosine Kinase (BTK) with an inhibition concentration (IC50) value of 13.7 nM. It effectively reduces the expression of phosphorylated BTK at Tyrosine 223 (p-BTK Y223) and phosphorylated Phospholipase C Gamma 2 at Tyrosine 1217 (p-PLC?2 Y1217), demonstrating anti-inflammatory properties.

• Smiles :

  C=CC(=O)N1CC[C@H](C1)N2C3=C4C(=CN=C4NC=N3)C(=N2)NC5=CC=C(C=C5)OC6=CC=CC=C6

• Molecular Formula :

  C26H23N7O2

• Molecular Weight :

  465.51

• Shipping Conditions :

  Cool pack

• Storage Temperature :

  -20°C