USP7-IN-4

• Target:

  MDM-2/p53|||DUB|||p53

• Related Pathways:

  Apoptosis|||DNA Damage/DNA Repair|||Ubiquitination|||Cell Cycle/Checkpoint

• Purity:

  >99.99%

• Bioactivity:

  USP7-IN-4 (USP7 inhibitor ALM4) is a non-competitive, potent and selective inhibitor of USP7 (ubiquitin-specific protease 7) with an IC50 = 6 nM, up-regulates p53 and p21, down-regulates MDM2, increases the level of ubiquitination of MDM2, and exhibits anti-proliferative activity in a variety of cancer cell lines, with an EC50 = 2.0 nM in RS4;11 (acute lymphoblastic leukemia cell line) .

• Smiles:

  CN1C(=C2C(C(=O)N(CC3(O)CCN(C(C[C@@H](C)C4=CC=CC=C4)=O)CC3)C=N2)=N1)C5=CC=C(CN)C=C5

• Molecular Formula:

  C29H34N6O3

• Molecular Weight:

  514.62

• Shipping Conditions:

  Cool pack

• Storage Temperature:

  -20°C

• CAS Number:

  2196243-57-7