CDK7-IN-20

• Target:

  Others|||GSK-3|||CDK

• Related Pathways:

  Others|||PI3K/Akt/mTOR signaling|||Stem Cells|||Cell Cycle/Checkpoint

• Bioactivity:

  CDK7-IN-20 is a potent, selective, and irreversible inhibitor of Cyclin-Dependent Kinase 7 (CDK7) with an IC50 value of 4 nM, exhibiting over 206-fold selectivity against related kinases [CDK1, CDK2, CDK3, CDK5, CDK6, CDK9, and CDK12]. It holds potential for research into autosomal dominant polycystic kidney disease (ADPKD) .

• Smiles:

  C=CC (=O) NC1=CC=C (C=C1) C (=O) NC2=NNC3=C2C=C (C=C3) C4=CC (=CN=C4) NC[C@H] (C5=CC=CC=C5) O

• Molecular Formula:

  C30H26N6O3

• Molecular Weight:

  518.57

• Shipping Conditions:

  Cool pack

• Storage Temperature:

  -20°C