LEM-14-1189

• Target:

  Histone Methyltransferase

• Related Pathways:

  Chromatin/Epigenetic

• Purity:

  0.9806

• Bioactivity:

  Lem-14-1189, a LEM-14 derivative, is a potent NSD inhibitor of the nuclear receptor binding SET domain, and has inhibitory effects on NSD1, NSD2, and NSD3, with IC50 of 418 ?M, 111 ?M, and 60 ?M, respectively. LEM-14-1189 has potential anticancer activity and can be used to study multiple myeloma (MM) and diseases of the blood system.

• Smiles:

  C1CCC2=C (C1) C3=C (S2) N=C (NC3=O) CN (CCCNC (=O) C4=CC5=CC=CC=C5C (=O) O4) CC6=NC7=C (C8=C (S7) CCCC8) C (=O) N6

• Molecular Formula:

  C35H34N6O5S2

• Molecular Weight:

  682.81

• Shipping Conditions:

  Cool pack

• Storage Temperature:

  -20°C

• CAS Number:

  2987501-17-5