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TTK inhibitor 3

CAT: 0931-T72757-01Size: 1 mgDry Ice: NoHazardous: No
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CAT#:0931-T72757-01Size:1 mg
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24/48H Stock Items & 2 to 6 Weeks non Stock Items.
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CAS Number
2820453-41-4
Target
Tyrosine Kinases
Related Pathways
Tyrosine Kinase/Adaptors
Purity
0.9944
Bioactivity
TTK inhibitor 3 (compound 25) is a selective inhibitor of TTK (Threonine Tyrosine Kinase) with an IC50 of 3.0 nM for TTK and 16.0 nM for CAL-51 cells. It inhibits tumor growth in CAL-51 xenograft models and TNBC (triple-negative breast cancer) PDX models.
Smiles
O=C1C2=CC(=CN2CCN1C=3C(=CC=CC3CC)CC)C=4N=C(N=C5NC=CC54)NC6=CC=C(C=C6OC)N7CCC(C(=O)N8CC9(C8)CN(C)C9)CC7
Molecular Formula
C42H49N9O3
Molecular Weight
727.9
Shipping Conditions
Ice Packs
Storage Temperature
-20°C

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