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UCK2 Inhibitor-3

CAT: 0931-T72696-01Size: 25 mgDry Ice: NoHazardous: No
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CAT#:0931-T72696-01Size:25 mg
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24/48H Stock Items & 2 to 6 Weeks non Stock Items.
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CAS Number
2376687-49-7
Target
DNA/RNA Synthesis, Others
Related Pathways
Cell Cycle/Checkpoint, Others, DNA Damage/DNA Repair
Bioactivity
UCK2 Inhibitor-3 is a non-competitive inhibitor of uridine-cytidine kinase 2 (UCK2), a pivotal enzyme in the pyrimidine salvage pathway, with an IC50 value of 16.6 μM. UCK2 can partially substitute for dihydroorotate dehydrogenase (DHODH) in infected or rapidly dividing cells, aiding uridine salvage. Additionally, UCK2 Inhibitor-3 inhibits DNA polymerase eta and kappa, with IC50 values of 56 μM and 16 μM, respectively.
Smiles
O=C1N=C(N=C2C1=CNN2C3=CC=C(F)C=C3)SCC(=O)NC4=CC=C(Br)C=C4
Molecular Formula
C19H13BrFN5O2S
Molecular Weight
474.31
Shipping Conditions
Ice Packs
Storage Temperature
-20°C

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Alternative Products

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HY-148396-01UCK2 Inhibitor-3
HY-148394-01UCK2 Inhibitor-1
MBS5811059UCK2 Inhibitor-2
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TU027757UCK2 3'UTR Luciferase Stable Cell Line
TU077757UCK2 3'UTR GFP Stable Cell Line
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K7465204Uck2 sgRNA CRISPR Lentivector (Rat) (Target 3)
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