CRIPGBM chloride

• Target:

  Caspase|||Apoptosis|||RIP kinase

• Related Pathways:

  Apoptosis|||NF-?B|||Proteases/Proteasome

• Purity:

  0.9975

• Bioactivity:

  CRIPGBM chloride is an apoptosis-promoting derivative present in GBM cancer stem cells with antitumor activity. It induces caspase-1 dependent cell apoptosis by interacting with receptor-interacting protein kinase 2 (RIPK2) and acting as a molecular switch. cRIPGBM chloride reduces the formation of pro-survival RIPK2/TAK1 complexes and increases the formation of pro-apoptotic RIPK2/caspase 1 complexes, which can be used to study brain tumors.

• Smiles:

  [Cl-].O=C1C=2C=CC=CC2C(=O)C3=C1N(C(=[N+]3CC4=CC=C(F)C=C4)C)CC=5C=CC=CC5

• Molecular Formula:

  C26H20ClFN2O2

• Molecular Weight:

  446.9

• Shipping Conditions:

  Cool pack

• Storage Temperature:

  -20°C

• CAS Number:

  2361988-77-2