CBB1007 hydrochloride

CAT: 0931-T72388-01Size: 25 mgDry Ice: NoHazardous: No
CAT#:0931-T72388-01Size:25 mg
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AVAILABILITY: InStock
24/48H Stock Items & 2 to 6 Weeks non Stock Items.
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CAS Number
2070014-96-7
Target
Others|||Histone Demethylase
Related Pathways
Chromatin/Epigenetic|||Others
Bioactivity
CBB1007 HCl is a cell-permeable amidino-guanidinium compound identified as a potent, reversible, and substrate-competitive inhibitor of LSD1 (IC50 = 5.27 ?M for hLSD1) . It effectively inhibits LSD1-mediated demethylation of H3K4Me2 and H3K4Me (IC50 ? 5 ?M), without affecting H3K4Me3 and H3K9Me2 demethylation, nor the activities of LSD2 and JARID1A. Moreover, CBB1007 increases the levels of H3K4Me2 and H3K4Me (IC50 ? 5 ?M) and activates epigenetically suppressed genes CHRM4/M4-ArchR and SCN3A in F9 cells (IC50 ? 3.74 ?M) . It preferentially inhibits the growth of pluripotent tumors with minimal impact on non-pluripotent cancer or normal somatic cells (IC50 ? 100 ?M) .
Smiles
COC(=O)C1=CC(=CC(=C1)C(=O)N2CCN(CC2)C(=O)C3=CC=C(C=C3)C(=N)N)CN4CCN(CC4)C(=N)N.Cl.Cl.Cl.Cl.Cl
Molecular Formula
C27H39Cl5N8O4
Molecular Weight
716.91
Shipping Conditions
Cool pack
Storage Temperature
-20°C

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