CBB1007 trihydrochloride

• Target :

  Others

• Related Pathways :

  Others

• Bioactivity :

  CBB1007 trihydrochloride is a cell-permeable amidino-guanidinium compound that acts as a potent, reversible and substrate competitive LSD1 selective inhibitor (IC50 = 5.27 ?M for hLSD1) . IC50 Value: 5.27 uM Target: hLSD1 CBB1007 efficiently can block LSD1-mediated demethylation of H3K4Me2 and H3K4Me (IC50 ? 5 ?M) with no effect on H3K4Me3 and H3K9Me2, and LSD2 and JARID1A activities. Increases H3K4Me2 and H3K4Me contents (IC50 ? 5 ?M), and causes activation of epigenetically suppressed CHRM4/M4-ArchR and SCN3A genes in F9 cells (IC50 ? 3.74 ?M) . CBB1007 was Shown to preferentially arrest the growth of pluripotent tumors with minimal effect on non-pluripotent cancer or normal somatic cells (IC50 ? 100 ?M) .

• Smiles :

  COC(=O)C1=CC(=CC(=C1)C(=O)N2CCN(CC2)C(=O)C3=CC=C(C=C3)C(=N)N)CN4CCN(CC4)C(=N)N.Cl.Cl.Cl

• Molecular Formula :

  C27H37Cl3N8O4

• Molecular Weight :

  643.99

• Shipping Conditions :

  Cool pack

• Storage Temperature :

  -20°C