CBB1007 trihydrochloride

CAT: 0931-MF-0146080-01Size: 25 mgDry Ice: NoHazardous: No
CAT#:0931-MF-0146080-01Size:25 mg
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24/48H Stock Items & 2 to 6 Weeks non Stock Items.
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Target
Others
Related Pathways
Others
Bioactivity
CBB1007 trihydrochloride is a cell-permeable amidino-guanidinium compound that acts as a potent, reversible and substrate competitive LSD1 selective inhibitor (IC50 = 5.27 ?M for hLSD1) . IC50 Value: 5.27 uM Target: hLSD1 CBB1007 efficiently can block LSD1-mediated demethylation of H3K4Me2 and H3K4Me (IC50 ? 5 ?M) with no effect on H3K4Me3 and H3K9Me2, and LSD2 and JARID1A activities. Increases H3K4Me2 and H3K4Me contents (IC50 ? 5 ?M), and causes activation of epigenetically suppressed CHRM4/M4-ArchR and SCN3A genes in F9 cells (IC50 ? 3.74 ?M) . CBB1007 was Shown to preferentially arrest the growth of pluripotent tumors with minimal effect on non-pluripotent cancer or normal somatic cells (IC50 ? 100 ?M) .
Smiles
COC(=O)C1=CC(=CC(=C1)C(=O)N2CCN(CC2)C(=O)C3=CC=C(C=C3)C(=N)N)CN4CCN(CC4)C(=N)N.Cl.Cl.Cl
Molecular Formula
C27H37Cl3N8O4
Molecular Weight
643.99
Shipping Conditions
Cool pack
Storage Temperature
-20°C

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