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CLK1-IN-3

CAT: 0931-T72039-01Size: 1 mgDry Ice: NoHazardous: No
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CAT#:0931-T72039-01Size:1 mg
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24/48H Stock Items & 2 to 6 Weeks non Stock Items.
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CAS Number
2922550-28-3
Target
DYRK, Autophagy, CDK
Related Pathways
Cell Cycle/Checkpoint, Autophagy, Tyrosine Kinase/Adaptors
Purity
0.9979
Bioactivity
Clk1-in-3 is a + selective and highly potent sexual Clk1 inhibitor with an IC50 of 5 nM and 300 pairs higher affinity than Dyrk1A. CLK1-IN-3 also showed highly effective inhibition of Clk2 and Clk4, with IC50 values of 42 and 108 nM, respectively. CLK1-IN-3 is effective in inducing autophagy in vitro and can be used for prevention and human treatment of acute liver injury (ALI) .
Smiles
O=C(NC=1C=NC=2NC=C(C=3C=NC=C(F)C3)C2C1)C4=CC=C(C=C4)N5CCN(C)CC5
Molecular Formula
C24H23FN6O
Molecular Weight
430.48
Shipping Conditions
Ice Packs
Storage Temperature
-20°C

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