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AG-205

CAT: 0931-T71827-01Size: 5 mgDry Ice: NoHazardous: No
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CAT#:0931-T71827-01Size:5 mg
Selected
24/48H Stock Items & 2 to 6 Weeks non Stock Items.
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CAS Number
442656-02-2
Target
Others, Akt, NF-κB
Related Pathways
Cytoskeletal Signaling, NF-κB, Others, PI3K/Akt/mTOR signaling
Bioactivity
(rac) -AG-205 serves as a robust inhibitor of the progesterone receptor membrane component 1 (Pgrmc1), crucial for inducing genes linked to sterol synthesis, notably the INSIG1 protein, which interacts with PGRMC1. Additionally, it plays a pivotal role in mitigating neuronal resistance to hypoxic ischaemia by inhibiting NF-kB signalling and the activation of the BDNF/PI3K/AKT pathway.
Smiles
CN1CC[C@@H]2[C@H](C1)c1cc(C)ccc1N2C(=O)CSc1nnnn1-c1ccc(Cl)cc1
Molecular Formula
C22H23ClN6OS
Molecular Weight
454.98
Shipping Conditions
Ice Packs
Storage Temperature
-20°C

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