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Cremastranone

CAT: 0931-T71488-02Size: 50 mgDry Ice: NoHazardous: No
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CAT#:0931-T71488-02Size:50 mg
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CAS Number
107585-69-3
Target
Others, VEGFR
Related Pathways
Angiogenesis, Others, Tyrosine Kinase/Adaptors
Bioactivity
Cremastranone is a natural antiangiogenic homoisoflavanone. Cremastranone inhibits the proliferation, migration, and tube formation ability of human retinal microvascular endothelial cells.
Smiles
O=C1C=2C(OCC1CC3=CC(O)=C(OC)C=C3)=CC(O)=C(OC)C2O
Molecular Formula
C18H18O7
Molecular Weight
346.33
Shipping Conditions
Ice Packs
Storage Temperature
-20°C

Chemical Information

Cremastranone

Cremastranone is a homoisoflavonoid that is 2,3-dihydro-4H-chromen-4-onethat is substituted by hydroxy groups at positions 5 and 7, a methoxy group at position 6, and a 3-hydroxy-4-methoxybenzyl group at position 3. It has been isolated from various plants, including the bulb of Cremastra appendiculata. It has a role as an angiogenesis modulating agent and a plant metabolite. It is a polyphenol, an aromatic ether and a homoisoflavonoid.

CAS Number107585-69-3
PubChem CID21676260
IUPAC Name5,7-dihydroxy-3-[(3-hydroxy-4-methoxyphenyl)methyl]-6-methoxy-2,3-dihydrochromen-4-one
Molecular FormulaC18H18O7
Molecular Weight346.3
XLogP2.8
Topological Polar Surface Area105
Hydrogen Bond Donor Count3
Hydrogen Bond Acceptor Count7
Rotatable Bond Count4
Heavy Atom Count25
Formal Charge0
Complexity470
SMILES
COC1=C(C=C(C=C1)CC2COC3=C(C2=O)C(=C(C(=C3)O)OC)O)O
InChI
InChI=1S/C18H18O7/c1-23-13-4-3-9(6-11(13)19)5-10-8-25-14-7-12(20)18(24-2)17(22)15(14)16(10)21/h3-4,6-7,10,19-20,22H,5,8H2,1-2H3
InChIKey
DSTDMPAJBBOFCE-UHFFFAOYSA-N
Chemical Structure
2D Structure
2D structure of Cremastranone
CAS: 107585-69-3
CID: 21676260
Formula: C18H18O7
MW: 346.3
Interactive 3D Structure
Loading 3D structure...
View on PubChemRaw 3D data
Computed Properties
PropertyValue
Molecular Weight346.3
XLogP32.8
Hydrogen Bond Donor Count3
Hydrogen Bond Acceptor Count7
Rotatable Bond Count4
Exact Mass346.10525291
Monoisotopic Mass346.10525291
Topological Polar Surface Area105 Ų
Heavy Atom Count25
Formal Charge0
Complexity470
Isotope Atom Count0
Defined Atom Stereocenter Count0
Undefined Atom Stereocenter Count1
Defined Bond Stereocenter Count0
Undefined Bond Stereocenter Count0
Covalently-Bonded Unit Count1
Compound Is CanonicalizedYes

Alternative Products

CatalogName
MBS5814026Cremastranone

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