KRC-108

CAT: 0931-T71382-01Size: 25 mgDry Ice: NoHazardous: No
CAT#:0931-T71382-01Size:25 mg
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24/48H Stock Items & 2 to 6 Weeks non Stock Items.
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CAS Number
1146944-35-5
Target
Trk receptor|||Others|||c-Met/HGFR|||Autophagy|||Apoptosis|||FLT
Related Pathways
Autophagy|||Tyrosine Kinase/Adaptors|||Others|||Apoptosis|||Angiogenesis
Bioactivity
KRC-108 is a multiple kinase inhibitor. KRC-108 is a potent inhibitor of Ron, Flt3 and TrkA as well as c-Met. KRC-108 inhibited oncogenic c-Met M1250T and Y1230D more strongly than wild type c-Met. The anti-proliferative activity of KRC-108 was measured by performing a cytotoxicity assay on a panel of cancer cell lines. The GI (50) values (i.e., 50% inhibition of cell growth) for KRC-108 ranged from 0.01 to 4.22 ?M for these cancer cell lines. KRC-108 was also effective for the inhibition of tumor growth in human HT29 colorectal cancer and NCI-H441 lung cancer xenograft models in athymic BALB/c nu/nu mice. This molecule should serve as a useful lead for inhibitors targeting kinases and may lead to new therapeutics for the treatment of cancer. (source: Invest New Drugs. 2012 Apr;30 (2) :518-23. doi: 10.1007/s10637-010-9584-2. Epub 2010 Nov 16.) .
Smiles
NC1=C(C2=NC=3C(O2)=CC=CC3)C=C(C=N1)C4=CN(N=C4)C5CCNCC5
Molecular Formula
C20H20N6O
Molecular Weight
360.41
Shipping Conditions
Cool pack
Storage Temperature
-20°C

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