KRC-00715

• Target:

  C-Met/HGFR

• Related Pathways:

  Tyrosine Kinase/Adaptors

• Bioactivity:

  KRC-00715 is an orally effective inhibitor of c-Met, exhibiting high selectivity with an IC50 of 9.0 nM. This compound specifically inhibits the growth of gastric cancer cell lines with high c-Met expression by inducing G1/S phase block, and reduces the activity of downstream signals, including Akt, Erk, and c-Met itself. In the gastric cancer cell line Hs746T, KRC-00715 demonstrates cytotoxicity with an IC50 of 39 nM and selectively inhibits the proliferation of cell lines that overexpress c-Met. Additionally, KRC-00715 decreases tumor size in Hs746T xenograft mouse models.

• Smiles:

  FC (F) (F) C=1C=C (C=CC1OCCN2CCOCC2) C3=NC4=C (N=NN4CC5OC6=CC=CN=C6NC5) N=C3

• Molecular Formula:

  C25H25F3N8O3

• Molecular Weight:

  542.51

• Shipping Conditions:

  Cool pack

• Storage Temperature:

  -20°C

• CAS Number:

  2079853-72-6