Patidegib HCl

CAT: 0931-MF-0145536-01Size: 25 mgDry Ice: NoHazardous: No
CAT#:0931-MF-0145536-01Size:25 mg
Selected
PRICE
AVAILABILITY: InStock
24/48H Stock Items & 2 to 6 Weeks non Stock Items.
Product image 1
1 / 1
CAS Number
1169829-40-6
Target
Smo|||Others
Related Pathways
Stem Cells|||Others
Bioactivity
Patidegip, laos known as Saridegib and IPI-926, is an orally bioavailable, cyclopamine-derived (for structure comparison see Fig 1) inhibitor of the Hedgehog (Hh) pathway with potential antineoplastic activity. Specifically, Hedgehog pathway inhibitor IPI-926 binds to and inhibits the cell membrane-spanning G-protein coupled receptor SMO, which may result in the suppression of Hh pathway signaling and a decrease in tumor cell proliferation and survival. SMO is activated upon binding of Hh ligand to the cell surface receptor Patched (PTCH) ; inappropriate activation of Hh signaling and uncontrolled cellular proliferation may be associated with SMO mutations.
Smiles
C[C@H]1[C@@]2(O[C@]3([C@]1(NC[C@@H](C)C3)[H])[H])CC(C)=C4[C@@](CC2)([C@]5([C@](C4)([C@]6(C)[C@](CC5)(C[C@H](NS(C)(=O)=O)CC6)[H])[H])[H])[H].Cl
Molecular Formula
C29H49ClN2O3S
Molecular Weight
541.23
Shipping Conditions
Cool pack
Storage Temperature
-20°C

Related Products

CatalogName
MF-0142114-01Etafenone HCl
MF-0097604-01Lecozotan HCl
MF-0092136-01Naphyrone HCl
MF-0047120-01Adrogolide HCl
MF-0092422-01Lophophorine HCl
MF-0045712-01Aftobetin HCl
MF-0092358-01Imarikiren HCl
MF-0145982-01Ofloxacin HCl
MF-0098596-01Ravidasvir HCl
MF-0145893-01Otamixaban HCl

Alternative Products

CatalogName
MBS5813877Patidegib HCl
201572Patidegib free base

Popular Products