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GLPG0259 A

CAT: 0931-T71274-02Size: 50 mgDry Ice: NoHazardous: No
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CAT#:0931-T71274-02Size:50 mg
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24/48H Stock Items & 2 to 6 Weeks non Stock Items.
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CAS Number
1195065-29-2
Target
Others
Related Pathways
Others
Bioactivity
GLPG0259 A is a small-molecule inhibitor of mitogen-activated protein kinase-activated protein kinase 5 (MAPKAPK5), a kinase enzyme that plays a role in important inflammatory pathways.
Smiles
C(C)(C)N1C[C@]2(N(C[C@@]1(C2)[H])C3=CC=C(NC=4C=5N(C(=CN4)C=6C=C(C(N)=O)OC6)N=CN5)C=C3)[H]
Molecular Formula
C24H26N8O2
Molecular Weight
458.52
Shipping Conditions
Ice Packs
Storage Temperature
-20°C

Chemical Information

Glpg-0259

GLPG-0259 is under investigation in clinical trial NCT01024517 (GLPG0259 Solid Formulation Bioavailability and Food Effect).

CAS Number1195065-29-2
PubChem CID44462738
IUPAC Name4-[8-[4-[(1S,4S)-5-propan-2-yl-2,5-diazabicyclo[2.2.1]heptan-2-yl]anilino]-[1,2,4]triazolo[1,5-a]pyrazin-5-yl]furan-2-carboxamide
Molecular FormulaC24H26N8O2
Molecular Weight458.5
XLogP2.5
Topological Polar Surface Area118
Hydrogen Bond Donor Count2
Hydrogen Bond Acceptor Count8
Rotatable Bond Count6
Heavy Atom Count34
Formal Charge0
Complexity746
SMILES
CC(C)N1C[C@@H]2C[C@H]1CN2C3=CC=C(C=C3)NC4=NC=C(N5C4=NC=N5)C6=COC(=C6)C(=O)N
InChI
InChI=1S/C24H26N8O2/c1-14(2)30-10-19-8-18(30)11-31(19)17-5-3-16(4-6-17)29-23-24-27-13-28-32(24)20(9-26-23)15-7-21(22(25)33)34-12-15/h3-7,9,12-14,18-19H,8,10-11H2,1-2H3,(H2,25,33)(H,26,29)/t18-,19-/m0/s1
InChIKey
YBFGSJUVEOYPIS-OALUTQOASA-N
Chemical Structure
2D Structure
2D structure of Glpg-0259
CAS: 1195065-29-2
CID: 44462738
Formula: C24H26N8O2
MW: 458.5
Interactive 3D Structure
Loading 3D structure...
View on PubChemRaw 3D data
Computed Properties
PropertyValue
Molecular Weight458.5
XLogP32.5
Hydrogen Bond Donor Count2
Hydrogen Bond Acceptor Count8
Rotatable Bond Count6
Exact Mass458.21787210
Monoisotopic Mass458.21787210
Topological Polar Surface Area118 Ų
Heavy Atom Count34
Formal Charge0
Complexity746
Isotope Atom Count0
Defined Atom Stereocenter Count2
Undefined Atom Stereocenter Count0
Defined Bond Stereocenter Count0
Undefined Bond Stereocenter Count0
Covalently-Bonded Unit Count1
Compound Is CanonicalizedYes

Alternative Products

CatalogName
561481GLPG0259
GTR19208106-01GLPG0259 A
A18357-5GLPG0259 5mg
A18357-50GLPG0259 50mg
A18357-100GLPG0259 100mg
A18357-10GLPG0259 10mg
A18357-25GLPG0259 25mg

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