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SR-33805

CAT: 0931-T71223-01Size: 25 mgDry Ice: NoHazardous: No
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CAT#:0931-T71223-01Size:25 mg
Selected
24/48H Stock Items & 2 to 6 Weeks non Stock Items.
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CAS Number
121346-32-5
Target
Calcium Channel, Others
Related Pathways
Membrane transporter/Ion channel, Others, Metabolism
Bioactivity
SR-33805 is a calcium channel antagonist potentially for the treatment of atherosclerosis and heart failure. SR-33805 restored the MI-altered cell shortening without affecting the Ca (2+) transient amplitude, suggesting an increase of myofilament Ca (2+) sensitivity in MI myocytes. A SR33805-induced sensitization of myofilament activation was found to be associated with a slight increase in myosin light chain-2 phosphorylation and a more significant decrease on troponin I (TnI) phosphorylation. Decreased TnI phosphorylation was related to inhibition of protein kinase A activity by SR-33805.
Smiles
S(=O)(=O)(C1=C(C(C)C)C=2C(N1C)=CC=CC2)C3=CC=C(OCCCN(CCC4=CC(OC)=C(OC)C=C4)C)C=C3
Molecular Formula
C32H40N2O5S
Molecular Weight
564.74
Shipping Conditions
Ice Packs
Storage Temperature
-20°C

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