ARQ-736

• Target :

  Others|||Raf

• Related Pathways :

  Others|||MAPK

• Bioactivity :

  ARQ 736 is a potent and selective BRAF inhibitor. ARQ 736 is selectively potent in killing cancer cell lines harboring at least one mutated BRAF allele. BRAF mutations were detected in over 60% of melanomas and may account for a significant proportion of colon cancer patients whose tumors are resistant to anti-EGFR therapy. The B-Raf protein is a key signaling molecule in the mitogen activated protein kinase (MAPK) signaling pathway and has been implicated in the pathogenesis of a variety of cancers.

• Smiles :

  [Na+].[Na+].Cn1ccc(n1)S(=O)(=O)N1CCC[C@H](C1)Nc1nccc(n1)-c1c(nc2occn12)-c1cccc(OCOP([O-])([O-])=O)c1

• Molecular Formula :

  C25H25N8Na2O8PS

• Molecular Weight :

  674.54

• Shipping Conditions :

  Cool pack

• Storage Temperature :

  -20°C

• CAS Number :

  1228237-57-7