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ARQ-736

CAT: 0931-T71184-01Size: 25 mgDry Ice: NoHazardous: No
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CAT#:0931-T71184-01Size:25 mg
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24/48H Stock Items & 2 to 6 Weeks non Stock Items.
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CAS Number
1228237-57-7
Target
Others, Raf
Related Pathways
Others, MAPK
Bioactivity
ARQ 736 is a potent and selective BRAF inhibitor. ARQ 736 is selectively potent in killing cancer cell lines harboring at least one mutated BRAF allele. BRAF mutations were detected in over 60% of melanomas and may account for a significant proportion of colon cancer patients whose tumors are resistant to anti-EGFR therapy. The B-Raf protein is a key signaling molecule in the mitogen activated protein kinase (MAPK) signaling pathway and has been implicated in the pathogenesis of a variety of cancers.
Smiles
[Na+].[Na+].Cn1ccc(n1)S(=O)(=O)N1CCC[C@H](C1)Nc1nccc(n1)-c1c(nc2occn12)-c1cccc(OCOP([O-])([O-])=O)c1
Molecular Formula
C25H25N8Na2O8PS
Molecular Weight
674.54
Shipping Conditions
Ice Packs
Storage Temperature
-20°C

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