ARQ 069

CAT: 0931-T10372-01Size: 25 mgDry Ice: NoHazardous: No
CAT#:0931-T10372-01Size:25 mg
Selected
PRICE
AVAILABILITY: InStock
24/48H Stock Items & 2 to 6 Weeks non Stock Items.
Product image 1
1 / 1
CAS Number
1314021-57-2
Target
Others|||FGFR
Related Pathways
Angiogenesis|||Others|||Tyrosine Kinase/Adaptors
Bioactivity
ARQ 069 (3.8-60 ?M; for 2 hours) reduces the degree of phosphorylation of FGFR (predominantly FGFR2) in a concentration-dependent manner, without decreasing ?-actin. ARQ 069 shows an affinity for FGFR2 of 5.2 ?M. ARQ 069 inhibits FGFR phosphorylation in Kato III cells (IC50: 9.7 ?M) . ARQ 069 targets the inactive forms of FGFR1 and FGFR2 kinases and inhibits their enzymatic activity. When ARQ 069 is preincubated with either phosphorylated FGFR1 or FGFR2, the potency of ARQ 069 in inhibiting Pyk2 phosphorylation is markedly reduced, with IC50 values determined to be greater than 30 and 24.8 ?M for FGFR1 and FGFR2, respectively. ARQ 069 exhibits at least a 20-fold preference for binding to the unphosphorylated, inactive forms of FGFR1 and FGFR2.
Smiles
NC=1N=C2C=3C([C@@H](CC2=CN1)C4=CC=CC=C4)=CC=CC3
Molecular Formula
C18H15N3
Molecular Weight
273.33
Shipping Conditions
Cool pack
Storage Temperature
-20°C

Related Products

CatalogName
T81748-01MRV03-069
T6209-01CW-069
T67927-01BAY-069
T6393-01ARQ 621
T14323-01ARQ 531
T71184-01ARQ-736

Alternative Products

CatalogName
XMIRXP-29bXMIRXpress lentivector miRNA-29b-3p with Xmotif
MMIR-2861-PA-1Mouse pre-microRNA Expression Construct mir-2861
PMIRH1826PA-1Human pre-microRNA Expression Construct Lenti-miR-1826
EXOFLOW810A-1Exo-APC Exosome FACS stain
SI501A-1pSIH1-H1-copGFP shRNA Cloning and Expression Vector
MZIP483-3p-PA-1miRZip-483-3p anti-miR-483-3p microRNA construct
CAS535R-1Transfection-ready hspCas9-nickase-T2A-RFP SmartNickase mRNA (Cas9 Nickase mutant with RFP marker)
PMIRH518dPA-1Human pre-microRNA Expression Construct Lenti-miR-518d
CD615B-1pCDH-UbC-MCS-EF1-Hygro cDNA Cloning and Expression Vector
EVLT-CD81-VA-PEV-LuminiteTM pCDH-MSCV-NLuc-CD81- EF1-Puro Expression Lentivirus

Popular Products