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LCRF-0004

CAT: 0931-T71177-01Size: 25 mgDry Ice: NoHazardous: No
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CAT#:0931-T71177-01Size:25 mg
Selected
24/48H Stock Items & 2 to 6 Weeks non Stock Items.
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CAS Number
1229611-73-7
Target
Kras, Others, Ras, c-Met/HGFR
Related Pathways
Tyrosine Kinase/Adaptors, Others, MAPK
Bioactivity
LCRF-0004 is a potent and selective RON receptor tyrosine kinase inhibitor. The RON receptor tyrosine kinase has been identified as an important mediator of KRAS oncogene addiction and is overexpressed in the majority of pancreatic cancers. Preclinical studies show that inhibition of RON function decreases pancreatic cancer cell migration, invasion, and survival and can sensitize pancreatic cancer cells to chemotherapy. RON receptor tyrosine kinase is a potential as a therapeutic target.
Smiles
O(C1=C2C(C=C(S2)C3=CN(C)C=N3)=NC=C1)C4=C(F)C=C(NC(=O)C5=C(C(F)(F)F)N(N=C5)C6=CC=CC=C6)C=C4
Molecular Formula
C28H18F4N6O2S
Molecular Weight
578.54
Shipping Conditions
Ice Packs
Storage Temperature
-20°C

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