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DW532

CAT: 0931-T71082-02Size: 50 mgDry Ice: NoHazardous: No
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CAT#:0931-T71082-02Size:50 mg
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CAS Number
1267949-42-7
Target
Others
Related Pathways
Others
Bioactivity
DW532 is one of simplified analogues of hematoxylin that has shown broad-spectrum inhibition on tyrosine kinases and in vitro anti-cancer activities. DW532 inhibited EGFR and VEGFR2 in vitro kinase activity (the IC50 values were 4.9 and 5.5 μmol/L, respectively), and suppressed their downstream signaling. DW532 dose-dependently inhibited tubulin polymerization via direct binding to tubulin, thus disrupting the mitotic spindle assembly and leading to abnormal cell division. In a panel of human cancer cells, DW532 (1 and 10 μmol/L) induced G2/M phase arrest and cell apoptosis, which subsequently resulted in cytotoxicity. Knockdown of BubR1 or Mps1, the two core proteins of the spindle assembly checkpoint dramatically decreased DW532-induced cell cycle arrest in MDA-MB-468 cells. Moreover, treatment with DW532 potently and dose-dependently suppressed angiogenesis in vitro and in vivo. (Acta Pharmacol Sin. 2014 Jul;35 (7) :916-28.)
Smiles
O=C1C=C(C=2C(=C(O)C(O)=CC2)O1)C3=CC(O)=C(OC)C=C3
Molecular Formula
C16H12O6
Molecular Weight
300.26
Shipping Conditions
Ice Packs
Storage Temperature
-20°C

Chemical Information

CID 53233418
CAS Number1267949-42-7
PubChem CID53233418
IUPAC Name7,8-dihydroxy-4-(3-hydroxy-4-methoxyphenyl)chromen-2-one
Molecular FormulaC16H12O6
Molecular Weight300.26
XLogP2
Topological Polar Surface Area96.2
Hydrogen Bond Donor Count3
Hydrogen Bond Acceptor Count6
Rotatable Bond Count2
Heavy Atom Count22
Formal Charge0
Complexity462
SMILES
COC1=C(C=C(C=C1)C2=CC(=O)OC3=C2C=CC(=C3O)O)O
InChI
InChI=1S/C16H12O6/c1-21-13-5-2-8(6-12(13)18)10-7-14(19)22-16-9(10)3-4-11(17)15(16)20/h2-7,17-18,20H,1H3
InChIKey
IHPLZLMGSYGDMA-UHFFFAOYSA-N
Chemical Structure
2D Structure
2D structure of CID 53233418
CAS: 1267949-42-7
CID: 53233418
Formula: C16H12O6
MW: 300.26
Interactive 3D Structure
Loading 3D structure...
View on PubChemRaw 3D data
Computed Properties
PropertyValue
Molecular Weight300.26
XLogP32
Hydrogen Bond Donor Count3
Hydrogen Bond Acceptor Count6
Rotatable Bond Count2
Exact Mass300.06338810
Monoisotopic Mass300.06338810
Topological Polar Surface Area96.2 Ų
Heavy Atom Count22
Formal Charge0
Complexity462
Isotope Atom Count0
Defined Atom Stereocenter Count0
Undefined Atom Stereocenter Count0
Defined Bond Stereocenter Count0
Undefined Bond Stereocenter Count0
Covalently-Bonded Unit Count1
Compound Is CanonicalizedYes

Alternative Products

CatalogName
GTR19208302-01DW532

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