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Maprotiline-d3 hydrochloride

CAT: 0931-T70960-01Size: 1 mgDry Ice: NoHazardous: No
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CAT#:0931-T70960-01Size:1 mg
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24/48H Stock Items & 2 to 6 Weeks non Stock Items.
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CAS Number
1329496-63-0
Target
Autophagy
Related Pathways
Autophagy
Bioactivity
Maprotiline-d3 is intended for use as an internal standard for the quantification of maprotiline by GC- or LC-MS. Maprotiline is a tricyclic antidepressant. It binds to the norepinephrine transporter (NET) and is selective for NET over the serotonin and dopamine transporters. Maprotiline also binds to the serotonin (5-HT) receptor subtype 5-HT2A, as well as histamine H1, muscarinic acetylcholine, α1-adrenergic, and dopamine D2 receptors. In vivo, maprotiline inhibits norepinephrine reuptake in rat brain and peripheral tissues. It reduces isolation-induced aggressive behavior and inhibits electrical foot-shock stimulation-induced belligerence in mice when administered at doses ranging from 3 to 10 mg/kg. Maprotiline also reduces aggressive behavior in rhesus monkeys housed in groups. Formulations containing maprotiline have been used in the treatment of depression and anxiety.
Smiles
Cl.[2H]C([2H])([2H])NCCCC12CCC(c3ccccc13)c1ccccc21
Molecular Formula
C20H21D3ClN
Molecular Weight
316.8873
Shipping Conditions
Ice Packs
Storage Temperature
-20°C

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