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JNJ-pan-AR

CAT: 0931-T70956-01Size: 25 mgDry Ice: NoHazardous: No
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CAT#:0931-T70956-01Size:25 mg
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24/48H Stock Items & 2 to 6 Weeks non Stock Items.
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CAS Number
1332390-06-3
Target
Others
Related Pathways
Others
Bioactivity
JNJ-pan-AR, a meylated analogue of JNJ-63576253, is a novel pan-AR antagonist with potent activity against wild-type and clinically relevant AR mutations including F877L. JNJ63576253, also known as TRC253, is a potent and orally active androgen receptor antagonist. TRC253 specifically binds to both wild-type and certain mutant forms of AR, thereby preventing androgen-induced receptor activation and facilitating the formation of inactive complexes that cannot translocate to the nucleus.
Smiles
O=C1C2(N(C(=S)N1C=3C=C(C(F)(F)F)C(C#N)=NC3)C4=CC=C(OC5CCN(C)CC5)C=C4)CCC2
Molecular Formula
C25H24F3N5O2S
Molecular Weight
515.55
Shipping Conditions
Ice Packs
Storage Temperature
-20°C

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