CB-1158-analog

• Target:

  Arginase|||Others

• Related Pathways:

  Others|||Immunology/Inflammation

• Bioactivity:

  CB-1158-analog, also known as Numidargistat-analog and INCB01158-analog, is a potent and orally active arginase inhibitor with IC50=89 nM) . CB-1158 blocked myeloid cell-mediated suppression of T cell proliferation in vitro and reduced tumor growth in multiple mouse models of cancer, as a single agent and in combination with checkpoint blockade, adoptive T cell therapy, adoptive NK cell therapy, and the chemotherapy agent gemcitabine. CB-1158 increased tumor-infiltrating CD8+ T cells and NK cells, inflammatory cytokines, and expression of interferon-inducible genes. CB-1158 may be potentially useful in renal cell cancer, breast cancer, non-small cell lung cancer, acute myeloid leukemia, and other tumor types where arginase-secreting MDSCs are known to play an immunosuppressive role. (see ADDITIONAL INFORMATION in this web page for CB-1158 structure confusion) .

• Smiles:

  C(CCCCB(O)O)(C(O)=O)(N)C1CCN(CC2=C(Cl)C=C(Cl)C=C2)CC1

• Molecular Formula:

  C18H27BCl2N2O4

• Molecular Weight:

  417.14

• Shipping Conditions:

  Cool pack

• Storage Temperature:

  -20°C

• CAS Number:

  1345810-21-0