CB-1158-analog

CAT: 0931-T70928-01Size: 25 mgDry Ice: NoHazardous: No

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CAT#:0931-T70928-01Size:25 mg

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24/48H Stock Items & 2 to 6 Weeks non Stock Items.

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CAS Number

1345810-21-0

Target

Arginase, Others

Related Pathways

Others, Immunology/Inflammation

Bioactivity

CB-1158-analog, also known as Numidargistat-analog and INCB01158-analog, is a potent and orally active arginase inhibitor with IC50=89 nM) . CB-1158 blocked myeloid cell-mediated suppression of T cell proliferation in vitro and reduced tumor growth in multiple mouse models of cancer, as a single agent and in combination with checkpoint blockade, adoptive T cell therapy, adoptive NK cell therapy, and the chemotherapy agent gemcitabine. CB-1158 increased tumor-infiltrating CD8+ T cells and NK cells, inflammatory cytokines, and expression of interferon-inducible genes. CB-1158 may be potentially useful in renal cell cancer, breast cancer, non-small cell lung cancer, acute myeloid leukemia, and other tumor types where arginase-secreting MDSCs are known to play an immunosuppressive role. (see ADDITIONAL INFORMATION in this web page for CB-1158 structure confusion) .

Smiles

C(CCCCB(O)O)(C(O)=O)(N)C1CCN(CC2=C(Cl)C=C(Cl)C=C2)CC1

Molecular Formula

C18H27BCl2N2O4

Molecular Weight

417.14

Shipping Conditions

Ice Packs

Storage Temperature

-20°C

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Alternative Products

Catalog	Name
206811	CB-1158-analog
A16864-100	CB-1158-analog 100mg
A16864-10	CB-1158-analog 10mg
A16864-1	CB-1158-analog 1mg
A16864-25	CB-1158-analog 25mg
A16864-5	CB-1158-analog 5mg
A16864-50	CB-1158-analog 50mg
MBS3841905-01	CB-1158
MBS5752868	CB-1158 dihydrochloride
A16929-10	Numidargistat (CB-1158) 10mg

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