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PF05020182

CAT: 0931-T70896-01Size: 25 mgDry Ice: NoHazardous: No
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CAT#:0931-T70896-01Size:25 mg
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24/48H Stock Items & 2 to 6 Weeks non Stock Items.
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CAS Number
1354712-92-7
Target
Others, Potassium Channel
Related Pathways
Others, Membrane transporter/Ion channel
Bioactivity
PF05020182 is novel potent and selective Kv7.2/4 potassium channel opener. PF-05020182 (2) significantly inhibits convulsions in the MES assay at doses tested, consistent with in vitro activity measure. The physiochemical properties, in vitro and in vivo activities of PF-05020182 support further development as an adjunctive treatment of refractory epilepsy. Facilitating activation, or delaying inactivation, of the native Kv7 channel reduces neuronal excitability, which may be beneficial in controlling spontaneous electrical activity during epileptic seizures.
Smiles
N(C(CC(C)(C)C)=O)C=1C(OC)=NC(=NC1OC)N2CCC(OC)CC2
Molecular Formula
C18H30N4O4
Molecular Weight
366.46
Shipping Conditions
Ice Packs
Storage Temperature
-20°C

Alternative Products

CatalogName
MBS5813438PF05020182

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