BPR1J-340

CAT: 0931-MF-0145107-01Size: 25 mgDry Ice: NoHazardous: No
CAT#:0931-MF-0145107-01Size:25 mg
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AVAILABILITY: InStock
24/48H Stock Items & 2 to 6 Weeks non Stock Items.
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CAS Number
1395051-72-5
Target
Apoptosis|||FLT|||Others
Related Pathways
Angiogenesis|||Tyrosine Kinase/Adaptors|||Others|||Apoptosis
Bioactivity
BPR1J-340 is a potent and selective FLT3 inhibitor with potential anticancer activity. BPR1J-340 was identified as a novel potent FLT3 inhibitor by biochemical kinase activity (IC50 approximately 25 nM) and cellular proliferation (GC50 approximately 5 nM) assays. BPR1J-340 inhibited the phosphorylation of FLT3 and STAT5 and triggered apoptosis in FLT3-ITD (+) AML cells. The pharmacokinetic parameters of BPR1J-340 in rats were determined. BPR1J-340 also demonstrated pronounced tumor growth inhibition and regression in FLT3-ITD (+) AML murine xenograft models. The combination treatment of the HDAC inhibitor vorinostat (SAHA) with BPR1J-340 synergistically induced apoptosis via Mcl-1 down-regulation in MOLM-13 AML cells, indicating that the combination of selective FLT3 kinase inhibitors and HDAC inhibitors could exhibit clinical benefit in AML therapy.
Smiles
N(C(=O)C1=CC=C(CN2CCN(C)CC2)C=C1)C=3C=C(NN3)C4=CC=C(CNC(NC=5C=C(CC)ON5)=O)C=C4
Molecular Formula
C29H34N8O3
Molecular Weight
542.63
Shipping Conditions
Cool pack
Storage Temperature
-20°C

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Alternative Products

CatalogName
MBS5813322BPR1J-340
MBS131218-01BPR1J-097
A16248-25BPR1J-097 25mg
MBS3609391-01BPR1J-097 hydrochloride
A16248-50BPR1J-097 50mg
A16248-10BPR1J-097 10mg
A16248-2BPR1J-097 2mg
A16248-5BPR1J-097 5mg
A16248-100BPR1J-097 100mg
A16248-10mM-DBPR1J-097 10mM * 1mL in DMSO

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